PGDMLT 201 MCQS 60-120

 61. The Fc receptor is a plasma membrane glycoprotein that binds to different immunoglobulin and triggers effective functions.

Which of the following Fc receptor is involved in the transfer of IgG from mother to fetus

(a) Fc€R

(b) FcRN

(c) FcµR

(d) FcγR

Ans: (b) ) FcRN

62. The immunoglobulin superfamily is the group of membrane proteins that possess one or more homologous immunoglobulin

domain. Which of the following is NOT immunoglobulin superfamily?

(a) T cell receptor

(b) beta2 microglobulin

(c) Insulin receptor

(d) Platelet-derived growth factor

Ans: (c) Insulin receptor

63. B-cell receptor consist of membrane-bound immunoglobulin and a small heterodimer protein required for signaling. Which of

the following is the heterodimer protein?

(a) Igα & Igβ

(b) Igµ & Igγ

(c) Igα & Igγ

(d) None of Above

Ans: (a) Igα & Igβ

64. Multiple Myeloma is characterized by excessive production of immunoglobulin and presence of light chain in urine. Which of the

following cells are responsible for the production of immunoglobulin

(a) T cells

(b) B-cells

(c) Plasma cells

(d) Dendritic cells

Ans: (c) Plasma cells

65. Which of the following complement is bound by IgG?

(a) C2a

(b) C2b

(c) C3a

(d) C3b

Ans: (d) C3b

66. Which of the following subclass of IgG molecule is the most potent activator of complement pathway?

(a) IgG1

(b) IgG2

(c) IgG3

(d) IgG4

Ans: (c) ) IgG3

67. Which of the following subclass of IgG does not readily cross the placental barriers?

(a) IgG1

(b) IgG2

(c) IgG3

(d) IgG4

Ans: (b) IgG2

68. Which of the immunoglobulin isotype have the shortest half-life?

(a) IgG

(b) IgM

(c) IgA

(d) IgE

Ans: (d) IgE

69. Which of the immunoglobulin isotype have the longest half-life?

(a) IgG

(b) IgM

(c) IgA

(d) IgE

Ans: (a) IgG

70. Which of the following antibody is an important host defense against encapsulated bacteria?

(a) IgG1

(b) IgG2

(c) IgG3

(d) IgG4

Ans: (b) ) IgG2

71.Which of the following immunoglobulin is the most abundant immunoglobulin in newborns?

(a) IgA

(b) IgM

(c) IgG

(d) IgD

Ans: (c) IgG

72.Whch of the following immunoglobulin is produced early in the primary response to infection?

(a) IgE

(b) IgA

(c) IgG

(d) IgM

Ans: (d) IgM

73.Which of the following immunoglobulin is the main host defense against parasititc infections?

(a) Secretory IgA

(b) IgG

(c) IgM

(d) IgE

Ans: (d) IgE

74.Which of the following immunoglobulin has the highest avidity of the immunoglobulins?

(a) IgA

(b) IgM

(c) IgE

(d) IgG

Ans: (b) IgM

75.0The order of percent of total immunoglobulin in serum is,

(a) IgM, IgA, IgG, IgD, IgE

(b) IgG, IgA, IgM, IgE, IgD

(c) IgG, IgA, IgM, IgE, IgD

(d) IgG, IgA, IgM, IgD, IgE

Ans: (d) IgG, IgA, IgM, IgD, IgE

76.Which of the following antibody is prominent antigen receptor expressed on B Cells?

(a) IgG

(b) IgA

(c) IgM

(d) IgE

Ans: (c) IgM

77.The antibody which is found in secretions is:

(a) IgD

(b) IgE

(c) IgG

(d) IgA

Ans: (d) IgA

78.Which of the following antibody directly take part in opsonization process?

(a) IgM

(b) IgG

(c) IgA

(d) IgE

Ans: (b) IgG

79.Complement fixation is one of the most important host defense against infections. The complement is activated by;

(a) IgM Only

(b) IgG only

(c) both (a) and (b)

(d) all five classes of antibodies activate complements.

Ans: (c) both (a) and (b)

80. Complement component C3 is cleaved by:

(a) C3b

(b) C3bBb

(c) Factor B

(d) Factor D

Ans: (b) C3bBb

81. The membrane attack complex in the complement pathway consists of:

(a) C3b3b,Bb

(b) C5b,6,7,8,9

(c) Colicins

(d) OH.

Ans: (b) C5b,6,7,8,9

82. Complement component C3b:

(a) directly injures bacteria.

(b) is an anaphylatoxin.

(c) is chemotactic.

(d) opsonizes bacteria.

Ans: (d) opsonizes bacteria

83. A complement component that is strongly chemotactic for neutrophils is:

(a) C3

(b) C3b

(c) C5a

(d) C5b

Ans: (c) C5a

84. The initial complement component that is bound by complement-fixing antibodies is:

(a) C1q

(b) C1s

(c) C3b

(d) C5a

Ans: (a) C1q

85. Several of the complement components are:

(a) Antibodies

(b) Cytokines

(c) Enzymes

(d) Glycolipids

Ans: (c) Enzymes

86. The classical and alternative pathways meet at complement component:

(a) C3

(b) C4

(c) C4b

(d) C5

Ans: (a) C3

87. One principal function of complement is to:

(a) bind antibodies attached to cell surfaces and to lyse these cells

(b) cross-link allergens

(c) inactivate perforins

(d) mediate the release of histamine

Ans: (a) bind antibodies attached to cell surfaces and to lyse these cells

88. The major role of the complement system is to work in conjunction with

(a) antibodies to lyse cells via the C8 and C9 components

(b) antibodies to lyse cells via the perforin molecules

(c) antibodies to opsonize cells

(d) the major histocompatibility complex for cell recognition

Ans: (a) antibodies to lyse cells via the C8 and C9 components

89. Major Histocompatibility Complex is a tight cluster of linked___________

(a) Carbohydrates

(b) Proteins

(c) Genes

(d) Lipid molecules

Ans: (c) Genes

90. What is the name of MHC in humans?

(a) HLA

(b) H2

(c) Adjuvants

(d) Haplotype

Ans: (a) HLA

91. All the individual of the same species has the same allele of MHC genes.

(a) True

(b) False

Ans: (b) False

92. Which of the following polypeptide is important for the expression of MHC I on the cell membrane?

(a) Interferons

(b) β2-microglobin

(c) Lymphokines

(d) Interleukins

Ans: (b) β2-microglobin

93. Which of these are non-professional antigen presenting cells?

(a) Macrophages

(b) Dendritic cells

(c) Fibroblast

(d) B lymphocytes

Ans: (c) Fibroblast

94. Name the cell which receives antigen presented by MHC molecule.

(a) Nk cells

(b) B-cells

(c) T-cells

(d) Macrophages

Ans: (c) T-cells

95. Name the class of MHC which is recognized by CD4 TH cell.

(a) MHC cannot recognize T cells

(b) MHC III

(c) MHC I

(d) MHC II

Ans: (d) MHC II

96. Which MHC molecule recognizes CD8 TC cells?

(a) MHC I

(b) MHC II

(c) MHC III

(d) HLA-C

Ans: (a) MHC I

97. Name the part of processed antigen that binds to the MHC molecule and recognized by T-cells?

(a) Immunoglobulin

(b) Agretope

(c) Epitope

(d) Chaperone

Ans: (b) Agretope

98. Which of the following statement is INCORRECT about superantigens?

(a) Viral or bacterial proteins

(b) Endogenous by nature

(c) Unique binding ability

(d) Activate a large number of T-cells

Ans: (b) Endogenous by nature

99. Major histocompatibility complex (MHC) gene polymorphism and alleles are associated with increased susceptibility of certain

diseases. One of the allele, B47 which is associated with

(a) Ankylosis spondylitis

(b) Reactive arthritis

(c) Reiter’s syndrome

(d) All of the above

Ans: (d) All of the above

100. Hereditary hemochromatosis is a disorder characterized by iron overload liver and other tissues. Which of the MHC allele is

associated with the highest relative risk for hereditary hemochromatosis?

(a) A13/B14 co-incidence

(b) B12/A3 co-incidence

(c) A3/B14 co-incidence

(d) None of the above

Ans: (c) A3/B14 co-incidence

101. Narcolepsy is a chronic neurological disorder that affects brain ability to control the sleep-wake cycle. Which of the follow MHC

allele is associated with it?

(a) DR1

(b) DR2

(c) DR3

(d) DR4

Ans: (c) DR3

102. Systemic lupus erythematosus is an autoimmune disorder characterized by chronic and systemic inflammation due to loss of

immune tolerance against nuclear autoantigen. The MHC allele associated with the susceptibility include

(a) DP beta 1

(b) DQ beta 1

(c) DR beta 1

(d) None of the above

Ans: (c) DR beta 1

103. Major Histocompatibility Complex (MHC-I) molecules are the cell surface proteins activates T cells and mediate effector T-cell

function. Which of the following class of MHC molecules activate cytotoxic T cells?

(a) MHC class I

(b) MHC class II

(c) MHC class III

(d) All of the above

Ans: (a) MHC class I

104. The MHC molecules are encoded by specific genes. Which of the following is an incorrect statement regarding MHC genes:

(a) MHC class I proteins are encoded by B, C & A genes

(b) MHC class II proteins are encoded by DP, DQ and DR genes

(c) Both MHC class I and MHC class II genes are present in the same region of chromosome

(d) MHC class I and MHC class II are encoded by genes located in the different region of chromosomes

Ans: (c) Both MHC class I and MHC class II genes are present in the same region of chromosome

105. The MHC proteins are highly polymorphic. The following factors contribute to the polymorphism, EXCEPT

(a) MHC proteins are present in haplotypes

(b) MHC is co-dominantly expressed

(c) MHC genes are highly conserved

(d) None of the above

Ans: (c) MHC genes are highly conserved

106. Which of the following statement is FALSE regarding MHC proteins

(a) MHC class I is a dimer consisting of two chains: one alpha chain (three subunits) and b2 microglobulin chain expressed outside the cell

membrane

(b) MHC class I is a dimer consisting of two chains: an alpha and a beta-chain each consisting of two subunits expressed outside the cell

membrane

(c) Both of the above

(d) None of the above

Ans: (d) None of the above

107. Beta2 microglobulin is a highly conserved subunit essential for expression of class I on the cell surface. Identify the correct

statement regarding Beta2 microglobulin gene

(a) It is located on the same chromosome as B, C, A genes

(b) It is located in a different chromosomal location than B, C, and A genes

(c) It is a part of MHC I gene cluster

(d) None of the above

Ans: (b) It is located in a different chromosomal location than B, C, and A genes

108. The following is the characteristic feature of peptide binding cleft for MHC class I proteins

(a) It consists of alpha 1 and alpha 2 subunits

(b) The pocket can bind to 8-10 amino acid peptide

(c) It is a close-ended pocket

(d) All of the above

Ans: (d) All of the above

109. The anchor residues are mostly present in the c-terminal end of the peptide and bind to the amino acid residue on the peptidebinding cleft. The anchor residues are

(a) Acidic amino acid

(b) Basic amino acids

(c) Hydrophobic amino acids

(d) None of Above

Ans: (c) Hydrophobic amino acids

110. The CD8 cell surface protein of T cells interact with …………….. of MHC class I molecules.

(a) alpha-1 subunit

(b) alpha-2 subunit

(c) alpha-3 subunit

(d) beta2- microglobulin

Ans: (c) alpha-3 subunit

111. Interferon-gamma is a cytokine that induces the expression of

(a) MHC class I

(b) MHC class II

(c) Both of Above

(d) None of Above

Ans: (c) Both of Above

112. The MHC expression is decreased by infection of some viruses namely

(a) Human Cytomegalovirus

(b) Hepatitis Virus

(c) Adenovirus 12

(d) All of the above

Ans: (d) All of the above

113. Many viruses produce a protein immunoevasin that interferes with antigen presentation by MHC class I molecules. The

immunoevasin interfere MHC presentation by

(a) Block peptide transport to TAP

(b) Inhibiting E3 ubiquitin ligase activity

(c) Block tapasin function

(d) All of the above

Ans: (d) All of the above

114. The antigen recognition by T cell depends on the presence of specific MHC molecules in the antigen-presenting cell which is

known as

(a) MHC-recognition

(b) MHC-restriction

(c) MHC-processing

(d) MHC-signaling

Ans: (b) MHC-restriction

115. Which of the following gene is not the part of MHC class I gene cluster

(a) TAP gene

(b) Tapasin gene

(c) Proteasome LMP gene

(d) TNF gene

Ans: (d) TNF gene

116. MHC molecules are necessary for T cell response. Which of the following function is mediated by MHC-T cell interaction?

(a) Immune Tolerance

(b) Cytotoxicity

(c) B-cell activation

(d) All of the above

Ans: (d) All of the above

117. The following is the characteristic feature of peptide binding cleft for MHC class II proteins

(a) It is formed by alpha1 and beta1 interaction

(b) The pocket binds to 13-18 amino acids

(c) MHC-II has open-ended peptide binding cleft

(d) All of the above

Ans: (d) All of the above

118. The CD4 protein of T helper cells binds and stabilizes the MHC class II/peptide structure. The subunit that interacts with CD4

cell surface protein is

(a) alpha1 and beta1 subunit

(b) alpha2 and beta2 subunits

(c) alpha1 and alpha2 subunits

(d) beta1 and beta2 subunits

Ans: (d) beta1 and beta2 subunits

119. Bare lymphocytes are the genetic disorder caused by a lack of class II molecules on the cell surface. This is associated with

(a) Mutation of the gene encoding MHC class II proteins

(b) The mutation that leads to MHC folding

(c) Mutation of transcription factor protein (CIITA) required for expression of MHC class II proteins

(d) None of the above

Ans: (c) Mutation of transcription factor protein (CIITA) required for expression of MHC class II proteins

120. All the individual of the same species has the same allele of MHC genes.

(a) True

(b) False

Ans: (b) False